Bioactive Materials for Bone Defects Replacement

Research topic:

Synthesis and clinical implementation of new ceramics biomaterials with functional characteristics close to the natural bone and tooth enamel, which were found to be excellent biocompatibility and bioactivity in clinical trials on animals.

Unique calcium phosphates nanomaterials were synthesized, which in terms of composition, morphology and structure are close to the mineral component of the hard tissue of vertebrates -ion- substituted non-stoichiometric calcium phosphate based hydroxyapatite (HA). A new model of HA crystallization from amorphous calcium phosphate during precipitation from the agues solutions is proposed. The nature and feature of structural changes in HA nanopowders during annealing. A new sintering activation effect has been found in HA nanopressing caused by the influence of impurities. Based on the results of studies of physical processes during synthesis and annealing of nano HA, created ceramics biomaterials with functional characteristics close to the natural bone and tooth enamel.

Materials that turned out to be excellent biocompatibility and bioactivity in animal experiments, implemented clinically; more than 480 successful orthopedic operations have been performed. Postoperative studies showed that created biomaterials are highly effective artificial substitutes and fillers for bone defects and are suitable for wide clinical use. Two PhD theses were defended (Rokhmistrov D.V., 2009), (A.V. Goncharenko, 2020); published more than 50 articles in high ranking foreign journals, which are referenced by the systemScopus.The results of the work were reported at European and numerous international scientific forums on the issues biomaterials and nanostructures in Germany, Spain, Poland, Greece and Ukraine.

Advantages:

• Low cost;
• Bioactivity (high integration with bones);
• High recovery speed (post-operative period: 6-12 months);
• International recognition.

Prospective calcium-phosphate biomaterials:

• Calcium-phosphate nanomaterials;
• Functional gradient materials;
• Needle-like crystals (whiskers)and fibers hydroxylapatite (HA).

Contact person

Ruslan Vovk
Doctor of Physics and Mathematics, Professor
Phone: +380 (57) 707-53-83, +380 (57) 707-54-19
E-mail: r.v.vovk@karazin.ua