Karazin University Scientists Research Polyphenolic Compounds to Combat Amyloid Diseases Under the EURIZON Program

Researchers at V. N. Karazin Kharkiv National University are working on a scientific project titled “Biomolecular Interactions of Amyloids: The Modulating Effect of Polyphenols,” aimed at studying polyphenolic compounds capable of preventing structural damage to proteins and cell membranes caused by amyloid aggregates.

The project is based at the Education and Research Institute "School of Physics and Technology" and is being implemented with the support of the EURIZON international program, which is designed to support the Ukrainian scientific community and promote international scientific cooperation.

As a result of the project, various classes of polyphenolic compounds have been identified, including binary and ternary combinations, whose anti-amyloid effects can be exerted at the level of both proteins and biomembranes. The data obtained lay the foundation for developing new strategies for the prevention and treatment of amyloid diseases.

The project is carried out in collaboration with international partner Prof. Mette Thomsen of the School of Engineering and Science at Aalborg University (Denmark), enhancing interdisciplinary scientific interaction and incorporating advanced technologies into the research.

Project Lead:

• Valeriia Trusova – Professor of the Department of Medical Physics and Biomedical Nanotechnology, School of Physics and Technology; Corresponding Member of the National Academy of Sciences of Ukraine.

Team Members:

• Halyna Horbenko – Professor of the Department of Medical Physics and Biomedical Nanotechnology, School of Physics and Technology

• Uliana Malovytsia – Associate Professor of the Department of Medical Physics and Biomedical Nanotechnology, School of Physics and Technology

This project exemplifies the high level of scientific research conducted at Karazin University, highlighting the significance of fundamental science in the future of medicine and the critical role of international collaboration in addressing complex biomedical challenges.